GIPR Antagonist Antibodies Conjugated to GLP-1 Peptide are Multispecific Molecules that Decrease Weight in Obese Mice & Monkeys — ASN Events

GIPR Antagonist Antibodies Conjugated to GLP-1 Peptide are Multispecific Molecules that Decrease Weight in Obese Mice & Monkeys (#106)

Les Miranda 1
  1. Amgen Inc., Thousand Oaks, CA, United States

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) regulate glucose and energy homeostasis. Targeting both pathways with GIP receptor (GIPR) antagonist antibody (GIPR-Ab) and GLP-1 receptor (GLP-1R) agonist, by generating GIPR-Ab/GLP-1 multispecific molecules, is an approach for treating obesity and its comorbidities. In mice and monkeys, these multispecific molecules reduce body weight (BW) and improve many metabolic parameters. Overall, these GIPR-Ab/GLP-1 molecules promote BW loss, and they may be used for treating obesity.

  1. Cell Rep Med. 2021 Apr 30;2(5):100263.
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